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Water Insecurity in Indigenous Canada
Water insecurity in Northern Indigenous communities in Canada is pervasive and complex with multiple dimensions and impacts. Yet the relevant literature is sparse, especially for Labrador. Our case study aimed to understand the...
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles.
João Pedro Ferrari-Souza, Firoza Z Lussier, Douglas T Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela CL Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L Benedet, Nicholas J Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T O'Brien, James B Rowe, Ann D Cohen, Oscar L Lopez, Dana L Tudorascu, Thomas K Karikari, William E Klunk, Victor L Villemagne, Jean-Paul Soucy, Serge Gauthier, Diogo O Souza, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Pedro Rosa-Neto, Tharick A Pascoal
Apr 17, 2023
Animal studies suggest that the apolipoprotein E ε4 (APOEε4) allele is a culprit of early microglial activation in Alzheimer's disease (AD). Here, we tested the association between APOEε4 status and microglial activation in...